A highperformance liquid chromatographic method for the estimation of berberine in the stem of tinospora cordifolia willd. The materials of this study were collected from tibet autonomous region. The record derives from tropicos data supplied on 20120418 which reports it as an accepted name record 20600675 with original publication details. Despite centuries of use in traditional medicine to treat various disorders, there is no highquality clinical. It is also an important ingredient of several ayurvedic medicines.
Rapid screening and identification of diterpenoids in. Guduchi, tinospora cordifolia, diet, ayurveda, ethnomedicine, tribal uses. How chinese tinospora is effective for various diseases is listed in repertory format. Hplc estimation of berberine in tinospora cordifolia and tinospora. Names of chinese tinospora in various languages of the world are also given. The genus tinospora includes 34 species, in which several herbs were used as traditional medicines by indigenous groups throughout the tropical and subtropical parts of asia, africa, and australia. Tinospora sinensis, a kind of chinese folk medicine, has functions of harmonizing qi and blood, dredging the channels and collaterals, calming and soothing the nerves. The calibration curve for b 1 was found to be linear over the range 0. Female plants have rarely been collected, suggesting that it has largely been distributed by the vegetative propagation of male plants for medicinal purposes.
Request pdf hypoglycemic activity of tinospora sinensis linn leaves tinospora sinensis linn belongs to family menispermeace is traditionally used for the treatment of jaundice, liver. Chemical constituents from the stems of tinospora sinensis. They are mostly found in tropical and subtropical area of india. The dried stems of tinospora cordifolia were purchased from the local market of amritsar. Additionally, the neuroprotective activities and antioxidant effects of new compounds against a. It thrives easily in tropical regions, often growing to great heights, and climbing the trunks of large neem trees. Giloy is beneficial in fever, chronic fever, infections, low immunity, cancer, asthma, gout, rheumatoid arthritis. Hypoglycemic activity of tinospora sinensis linn leaves. It is said to be a tonic, antiperiodic, and a diuretic. Tinospora cordifolia, tinospora sinensis, berberine, hplc. Three new clerodane diterpene glycosides, tinosposinensides ac 1 3, and a new rearranged cadinane sesquiterpene glycoside, tinosinenside 4, were isolated from the stems of tinospora sinensis. Abstract tinospora cordifolia is a climbing deciduous shrub. Tinospora cordifolia, which is known by the common names heartleaved moonseed, guduchi, and giloy, is an herbaceous vine of the family menispermaceae indigenous to the tropical areas of bangladesh, india, myanmar, and sri lanka.
View tinospora cordifolia research papers on academia. The present anatomical study aids in differentiating pieces of woods of t. Selected species have been widely used in the traditional medicine systems in various dosage forms to treat liver disorders. Tinospora cordifolia guduchi, a reservoir plant for therapeutic applications. Morphology of tinospora cordifolia a steam b root c leaves d flower e fruit f seed. Herein, an analytical method was developed for rapid screening and identification of diterpenoids in t. Tinospora crispa is a very commonly used medicinal plant in the philippines. Tinospora cordifoliaguduchi is a widely used shrub in folk and ayurvedic systems of medicine. It is a promising anticancer herb and may provide benefits for people with diabetes. Tinospora cordifolia, which is known by the common names heartleaved moonseed, gaduchi, and giloya, is an herbaceous vine of the family menispermaceae indigenous to the tropical areas of bangladesh, india, myanmar, and sri lanka. Merrill and tinospora cordifolia growing on azadirachta indica a. The extensive literature survey revealed tinospora species to be a group of important medicinal plants used for the ethnomedical treatment of colds, headaches, pharyngitis, fever, diarrhea, oral. Comparative immunomodulation potential of tinospora cordifolia.
Andean bryophytes bolivia checklist catalogue of new world grasses ecuador catalogue flora mesoamericana madagascar catalogue moss flora of china peru checklist system details. Tinospora sinensis in the germplasm resources information network grin, u. Stem stem of this plant is rather succulent with long, filiform, fleshy and climbing in nature. Tinospora has long been used in india as a medicine and in the preparation of a starch known as gilaekasat or as palo. Introduction tinospora cordifolia belonging to the family menispermaceae is well known in ayurveda as guduchi. The plant materials were dried under shade and ground to a coarse powder. It has been traditionally used as folk medicine for treating debility, dyspepsia, rheumatism, gonorrhea. To supplement amrita ghrita tinospora cordifolia with ghee and ginger, take 10 15 g, once a day. Chemical constituents from the stems of tinospora sinensis and. Names of tinospora cordifolia in various languages of the world are also given. Tinospora cordifolia has anticancer, immune stimulating, nerve cell protecting, antidiabetic, cholesterollowering and liverprotective actions.
Chinese tinospora herb uses, benefits, cures, side effects. Not enough is known about the use of tinospora cordifolia during pregnancy and breastfeeding. Tinospora cordifolia contains many different chemicals that might affect the body. Tinospora crispa is widely used for a variety of internal complaints. Some chemicals might have activity against cancer cells in test animals. Several medicinal plants have been assessed as endangered, vulnerable and threatened due to over harvesting or unskillful harvesting. Tinospora cordifolia and related species such as tinospora crispa and tinospora rumphii boerl are used in ayurvedic and jamu herbal medicine. The extensive literature survey revealed tinospora species to be a group of important medicinal plants used for the ethnomedical treatment of colds, headaches, pharyngitis, fever, diarrhea. Sipai babu nirmala college of pharmacy, guntur dist, a. All structured data from the file and property namespaces is available under the creative commons cc0 license. All chemicals, reagents and solvents used in quantitative analysis and chemical investigation were of analytical grade and lab grade procured from e.
Tinospora cordifolia is a large deciduous, extensively spreading climbing shrub with a number of coiling branches. How tinospora cordifolia is effective for various diseases is listed in repertory format. The chemical constituents and diverse pharmacological importance. Diterpenoids are considered the major active compounds in tinospora sinensis in virtue of their special structures and activities. Those species in this genus have traditionally been used as therapeutic remedies table 1.
In thailand, an infusion from the stem is used to treat jaundice, cholera, malaria, and against worms in children 310. General information tinospora sinensis is a deciduous, climbing shrub producing stems up to 20 metres long that twine around other plants for support. New lignan glucosides from the stems of tinospora sinensis. Different parts of tinospora have following type of morphology. The name tinospora cordifolia has also been applied to tinospora sinensis.
Jul 03, 2015 tinospora cordifolia giloy in hindi and guduchi in sanskrit is an important immunomodulator herb. Tinospora cordifolia herb uses, benefits, cures, side. Hplc estimation of berberine in tinospora cordifolia and. Tinospora cordifolia, tinospora malabarica and tinospora crispa. There is a growing demand for plant based medicines, health products, pharmaceuticals, food supplements, cosmetics etc. Introduction tinospora sinensis kuanjinteng in chinese is commonly known as gurch and belongs to the family menispermaceae, which is mainly distributed in the tropical parts of the eastern hemisphere. Menispermaceae is one of the most widely used shrub from the ancient medicinal history of ayurveda as a medicine.
Comparative hepatoprotective potential of tinospora. A sesquiterpene glycoside and phenylalanine derivatives. Among the isolates, fifteen compounds were examined for their antiinflammatory. Conservation strategies need to be adopted for continuous supply to meet the everincreasing demands and sustainable utilization of resources. This name is the accepted name of a species in the genus tinospora family menispermaceae. Chemical constituents from the stems of tinospora sinensis and their bioactivity. Fiftyseven compounds were purified from the stems of tinospora sinensis, including three new compounds characterized as a. Others might increase the activity of the bodys immune system.
The specific name campylus sinensis thus clearly refers to the species of tinospora formerly known as t. Media in category tinospora sinensis the following 26 files are in this category, out of 26 total. Usda, ars, germplasm resources information network. The safety of longterm use, more than 8 weeks, is not known. Uses, benefits, cures, side effects, nutrients in tinospora cordifolia. Journal of medicinal plants studies tinospora cordifolia. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Plants have been one of the important sources of medicines since the beginning of human civilization. All structured data from the file and property namespaces is available under the creative commons cc0. Phytochemical and biological analysis of tinospora cordifolia.
Tinospora cordifolia seems to be safe when used shortterm. Pdf during botanical studies conducted in thiruvannamalai district of tamil nadu state, india as a part of compilation of the district flora. Tinospora cordifolia is widely used in indian ayurvedic medicine. Tinospora cordifolia herb uses, benefits, cures, side effects. Tinospora cordifolia is also responsible for decreasing the tissue damage caused by radiation, the side effects of some forms of chemotherapy and speeding healing of diabetic foot ulcers 34. The structures of new compounds were determined on the basis of 1 d and 2 dnmr spectroscopy and hresims. Tinospora cordifolia giloy in hindi and guduchi in sanskrit is an important immunomodulator herb. A new sesquiterpene glycoside and a new amide have been isolated from the stems of tinospora sinensis. Most research has been done in test tubes or in animals. Ayurvedic practice without this herb may not be possible. To supplement tinospora cordifolia, take 1g of a 5% bitters water extract of the stem. Not enough is known about the use of tinospora cordifolia during pregnancy.
Fiftyseven compounds were purified from the stems of tinospora sinensis, including three new compounds characterized as a lignan 1, a pyrrole alkaloid 11, and a benzenoid 17, respectively. A sesquiterpene glycoside and phenylalanine derivatives from. Tinospora cordifolia supplement health benefits, dosage. Aim of this study was to evaluate the comparative efficacy of tinospora cordifolia willd.
Oct 12, 2011 tinospora cordifolia has anticancer, immune stimulating, nerve cell protecting, antidiabetic, cholesterollowering and liverprotective actions. Uses, benefits, cures, side effects, nutrients in chinese tinospora. Comparative studies of the immunomodulatory activity of tinospora cordifolia and tinospora sinensis. Leaves 1114 x 911 cm, broadly ovate, apex acuminate, base cordate, 57ribbed, scabrous above, densely white tomentose below. The reference to bracteis 3lobis could refer to the 3 outer sepals. List of various diseases cured by chinese tinospora.
It is an important drug used by ayurveda practitioners in various diseased conditions and also for maintenance of health. There isnt enough information to know the effects of tinospora. A new sesquiterpene glycoside, tinosinenside a 1 and a new amide 2 along with six known compounds 38 were isolated and identified from the nbuoh soluble portion of tinospora sinensis. Tinospora cordifolia guduchi, a reservoir plant for. Tinospora cordifolia is commonly known as guduchi, amrita sanskrit, giloe, gulancha bengali, giloya hindi, galo gujrati, teppatige telagu, heartleaf moonseed hindi 7. Vegetative propagation of tinospora cordifolia a folkloric. The record derives from tropicos which reports it as an accepted name record 20600675 with original publication details. Despite centuries of use in traditional medicine to treat various disorders, there is no highquality clinical evidence that it has any effect on diseases. The linear regression equation for the calibration curve was y 123512x 78787, where y is the peak area ratio of b 1 and x is the concentration of b 1. Their structures were established on the basis of chemical and spectroscopic findings.
The methanolic extract would be studied further for isolation and characterization of active components for lead optimization studies. Immune stimulating properties of a novel polysaccharide from the medicinal plant tinospora cordifolia. List of various diseases cured by tinospora cordifolia. The extract of guduchi guduchi satva is adulterated with powderflour of potatosweet potato arrowrootbanana. The standard dose is 300mg, taken three times a day. Anticancer, cytotoxicity, invitro, mdamb231, breast cancer, tinospora cordifolia 1. Tinospora cordifolia was shown to possess cytotoxic activity against human breast cancer cells. Issn 23203862 evaluation of anticancer activity of stem. Oct 09, 2018 tinospora cordifolia, also known as guduchi or amrita, is an immune system boosting herb that can potently reduce the symptoms of allergic rhinitis. Department of agriculture agricultural research service. On the basis of our investigations, they are clinically applied for the treatment of fever and parasitic diseases, mouth, skin, respiratory, and urinary tract infections, oral ulcer, and diabetes, in addition to being an adjunctive therapy in cancer and to. Studies on the constituents of the stems of tinospora sinensis, ii.
1368 425 336 974 1128 1265 343 47 616 415 562 1315 946 1326 243 1171 171 735 374 1312 699 636 818 1157 977 283 244 83 635 645 237 824 29 542 378 315 223 1391 1252 807 597 947 455 443 574 976